CellMaxx Activates Natural Killer Cell To Fight Cancer

Natural Killer Cell Kills Tumor , Cancer and Viruses

Natural Killer (NK) cells were initially named based on the observation that they had cytolytic function in the absence of any specific kind of immunization. NK cells can release a bounty of cytokines and chemokines, including TNF-α, IFN-γ, IL-3, IL-10, GM-CSF, G-CSF, CCL2, CCL3, CCL4, CCL5, XCL1, and CXCL8. Type I IFNs, IL-2, IL-12, IL-15, and IL-18 are all potent activators of NK cells. NK cells are a vital arm of innate immunity and participate in surveillance against viral-infection and tumor cells.

Originating from the thymus, NKT (Natural Killer T) cells represent a combination of T cell and NK cell attributes/markers. They express a T cell receptor (TCR) complex and several NK cell markers. The ability of these cells to produce Th1 and Th2-related cytokines has implicated them in several fields, including transplantation, tumors, autoimmunity, and allergy.

MECHANICM OF NK CELLS

The scanning mechanism of NK cells is what allows them to maintain surveillance for tumor cells and virus-infected cells. Both tumor cells and virus-infected cells can either decrease expression of self markers (i.e., MHC Class I) or overexpress ligands that activate NK cells.

In humans, the major receptors responsible for tumor recognition by NK cells include NKp46, NKp30, NKp44, DNAM-1, and NKG2D. The corresponding ligands of some of these receptors have been identified: MICA/B and the ULBPs for NKG2D; PVR and Nectin-2 for DNAM-1; and B7-H6 for NKp30.

But, viruses and tumor cells can use the NK cell’s mechanism against them. Tumors and virus-infected cells have evolved the capability to shed soluble NK cell ligands that serve as decoys. In mice deficient for DNAM-1, NKp46, or NKG2D, tumors altered their expression of ligands (perhaps because they were brazen enough to realize NK cells could not recognize them).

To learn more about NK cell cytotoxicity, see this video below.

Natural Killer Cell Kills Tumor,Cancer and Viruses

by  on August 9, 2016 in CellmaxxCellmaxx dan Kanser

Natural Killer Cell Kills Tumor , Cancer and Viruses

Natural Killer (NK) cells were initially named based on the observation that they had cytolytic function in the absence of any specific kind of immunization. NK cells can release a bounty of cytokines and chemokines, including TNF-α, IFN-γ, IL-3, IL-10, GM-CSF, G-CSF, CCL2, CCL3, CCL4, CCL5, XCL1, and CXCL8. Type I IFNs, IL-2, IL-12, IL-15, and IL-18 are all potent activators of NK cells. NK cells are a vital arm of innate immunity and participate in surveillance against viral-infection and tumor cells.

Originating from the thymus, NKT (Natural Killer T) cells represent a combination of T cell and NK cell attributes/markers. They express a T cell receptor (TCR) complex and several NK cell markers. The ability of these cells to produce Th1 and Th2-related cytokines has implicated them in several fields, including transplantation, tumors, autoimmunity, and allergy.

MECHANICM OF NK CELLS

The scanning mechanism of NK cells is what allows them to maintain surveillance for tumor cells and virus-infected cells. Both tumor cells and virus-infected cells can either decrease expression of self markers (i.e., MHC Class I) or overexpress ligands that activate NK cells.

In humans, the major receptors responsible for tumor recognition by NK cells include NKp46, NKp30, NKp44, DNAM-1, and NKG2D. The corresponding ligands of some of these receptors have been identified: MICA/B and the ULBPs for NKG2D; PVR and Nectin-2 for DNAM-1; and B7-H6 for NKp30.

But, viruses and tumor cells can use the NK cell’s mechanism against them. Tumors and virus-infected cells have evolved the capability to shed soluble NK cell ligands that serve as decoys. In mice deficient for DNAM-1, NKp46, or NKG2D, tumors altered their expression of ligands (perhaps because they were brazen enough to realize NK cells could not recognize them).



To learn more about NK cell cytotoxicity, see this video below.

NK cells mainly derived from the bone marrow, NK cells routinely survey immune cells by checking them for the expression of certain markers. Normal, healthy cells display markers that naturally inhibit NK cell activation. However, upon stress, cells may downregulate markers like MHC I. If an NK cell sees a cell is “missing self” or has an overabundance of NK activating ligands, the NK cell will target that cell for destruction, primarily killing through granzyme and perforin release and FasL-mediated cytotoxicity. In this manner, NK cells help to monitor for viral infection and tumor cells..

CELLMAXX SUPPORT THE RELEASE OF NK CELL TO KILL CANCER

Most recent studies also indicated by consuming AFA on a regular basis will support the natural release of Natural Killer (NK) cells from the human body. This Most Unique SUPERFOOD also contains a full spectrum of 64 micro-nutrients, including Glyco-protein, 12 vitamins, 27 essential minerals, 11 pigments, simple carbohydrates, lipids and biologically active enzymes, exactly similar to that required by the human body. It is very rich in vitamin B-12, Glyco-Protein, Phenylethylamine (PEA), Omega 3-Fatty Acids, Polysaccharide, Phycocyanin and Beta-Carotene. Therefore, AFA is known to be the most nutrient-dense balanced whole food on this planet.

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